Spun

As Ross (Jason Schwartzman) navigates the tumultuous world of addiction, his life becomes increasingly entwined with the enigmatic Spider Mike (John Leguizamo), a methamphetamine dealer whose toxic relationship with Cookie (Mena Suvari) is a powder keg waiting to explode. Amidst this chaos, Ross forms an unlikely bond with Nikki (Brittany Murphy), a fellow addict who introduces him to her volatile boyfriend, "The Cook" (Mickey Rourke). This shady character supplies Spider Mike's operation with drugs from a seedy motel room meth lab, and in exchange for bringing Nikki home, he bestows upon Ross a small stash of the addictive substance. The Cook also makes it clear that he'll be calling on Ross if he needs a reliable driver.

Back at his apartment, Ross is bombarded by messages from his mother and former girlfriend Amy, wishing him a happy birthday. Assuming Amy still harbors feelings for him, Ross begins leaving incoherent messages on her answering machine, only to later indulge in an intense, drug-fueled hallucination at the local strip club. He takes April (Chloe Hunter), one of his many conquests, home and embarks on a sexual frenzy that culminates with him duct-taping her eyes and mouth shut to keep her quiet while he tends to an urgent phone call from The Cook regarding Nikki's beloved dog, Taco, which requires emergency veterinary care.

Meanwhile, two bumbling policemen (Peter Stormare and Alexis Arquette) working in tandem with a TV crew are on the hunt for Spider Mike's operation. Under false pretenses, they raid the trailer of another of Spider Mike's customers, Frisbee (Patrick Fugit), and his obese mother, threatening to turn them over to authorities unless Frisbee agrees to help them take down Spider Mike in an ill-fated drug bust. As Ross's life careens out of control, he finds himself trapped in a vicious cycle of addiction, violence, and desperation.

As the tumultuous evening wears on, Ross returns to his apartment, bearing gifts of contrition for April's beleaguered soul. The enigmatic Cook, meanwhile, summons a prostitute to his motel room, but when she arrives, his tawdry tryst with Nikki ends in acrimony and separation. Nikki then reaches out to Ross, imploring him to ferry her back to the neon-lit streets of Las Vegas, leaving April still helplessly bound to the bed. As Ross and Nikki embark on their journey, Frisbee, now sporting a wire, visits Spider Mike, hoping to score some meth and facilitate his own downfall. However, Cookie's attempts at seductive revenge are short-circuited when she discovers the wire, leading to a chaotic confrontation that culminates in Spider Mike's testicular torment and the simultaneous arrest of both him and Cookie. Frisbee is whisked away to the hospital, where he will no doubt nurse his wounds.

As Ross and Nikki eventually return to his apartment, they find April missing, having been spirited away by her lesbian neighbor, Deborah Harry. This development serves as a poignant reminder that some relationships are destined to remain intractable. With Nikki safely deposited at the bus station, Ross and she share a bittersweet kiss, their lips lingering on the promise of a reunion should he ever find himself back in Sin City.

In the midst of this emotional turmoil, the Cook's meth lab is consumed by flames, leaving his motel room a smoldering ruin. He flees to an adult film store, only to be apprehended by authorities after the owner, Rob Halford, sounds the alarm. Upon his release on bail, the Cook reaches out to Ross, requesting a ride to the city, where he hopes to reconnect with a dealer and rekindle his chemical dependencies. Ross agrees, motivated in part by his desire to reunite with Amy, who also calls the city home.

The dealer proves a generous benefactor, bestowing upon the Cook a bounty of cash, meth, and equipment for a new lab. In exchange for this largesse, the Cook offers Ross six months' worth of meth, on the condition that he serve as his chauffeur. Ross accepts, with the proviso that he be allowed to see Amy first. Her response is a poignant reminder that some relationships are irreparably damaged by addiction and neglect: she rejects him outright, demanding only $100 from the $450 he owes her.

As the evening draws to a close, the Cook drives a despondent Ross out to an abandoned trailer on the outskirts of town, where he sets up a new lab. His efforts ultimately prove self-destructive, as the trailer is reduced to rubble and he meets his own demise in the ensuing inferno.