In the wake of a catastrophic mission in Phnom Penh, Cambodia, which saw a tragic loss of lives, CIA Global Response team leader Jake Alexander finds himself at a crossroads. His once formidable team, comprising of Sonia Dekker, Tom Benton, Maria Lopez, and Ben Harrison, faces disbandment at the hands of the CIA. Despite clear directives from Agent Jessica Thompson, they remain undeterred and decide to continue their quest to capture the infamous arms dealer Gino Orsetti, financed by the wealthy Hong Kong entrepreneur Katarina Sokolov.

The team reconvenes in vibrant Bangkok, where Tom devises a clever plan to arrange a meeting with Orsetti by masquerading as a potential buyer for his illicit organ trade. Meanwhile, CIA Agent Alec Hayes, eager to dismantle Alexander’s operation, sends a hitman to eliminate him and his team. However, the assassin’s efforts fall short.

After a brief stint in Thailand, the crew heads to Manila, where Sonia and Tom engage directly with Orsetti while the rest of the team monitors the operation from the shadows. Tension escalates as the transaction reaches its critical point; amidst the chaos, Sonia and Tom launch an attack on Orsetti, igniting a fierce shootout that ensues on the streets.

In the aftermath, Alexander confronts Orsetti in an intense struggle, ultimately ending the criminal’s reign of terror. However, just two weeks later, after enduring a grueling interrogation by Thompson about the events surrounding Orsetti’s death, Alexander makes the difficult decision to resign from the CIA and slips into anonymity. His loyal teammates guard his whereabouts, much to the frustration of Agent Hayes, who becomes increasingly determined to track Alexander down, culminating in a harrowing drone strike as he finally reunites with his lover in the serene countryside of the Philippines.