Dracula, voiced by Adam Sandler, in the year 1895, is not just the owner but the visionary creator of Hotel Transylvania, a luxurious five-star haven designed to shelter monsters from the threat posed by human beings. With the utmost care, he crafts this sanctuary to protect his beloved daughter Mavis from what he perceives as the inherent dangers of human civilization. Raised within its walls, Mavis knows only the safety of her father’s domain, which is fortified by ominous barriers, including a perilous jungle and a foreboding graveyard, ensuring that no human can breach its defenses.

Fast forward to the present day, Dracula hosts a grand celebration to honor Mavis’s 118th birthday, inviting an ensemble of legendary monsters to join in the festivities. Among the guests are familiar faces like Frankenstein’s Monster, played by Kevin James, his wife Eunice, Murray the Mummy, and Wayne and Wanda Werewolf, along with the Invisible Man, Bigfoot, and other creatures of the night. Yet, Mavis, curious about the world beyond, longs to explore life outside the hotel, prompting her father to concoct an elaborate ruse to scare her away from the human world he deems dangerous.

However, his plans go awry when a regular young traveler, Jonathan, portrayed by Andy Samberg, inadvertently stumbles upon the hotel after wandering through the nearby woods. Once inside, Dracula’s frantic attempts to conceal Jonathan from the hotel’s inhabitants lead to some comedic chaos, as he disguises him as a Flesh Golem named Johnny-stein, claiming he is a relative of one of Frank’s body parts. The secret must remain hidden to protect both the hotel’s safety and the sanctuary it provides for its monstrous guests. Yet, when Mavis discovers Jonathan, Dracula is forced to spin a new tale, asserting that Jonathan is also a monster who is 121 years old, and he proposes to organize Mavis’s birthday party through a youthful lens.

As Mavis interacts with Jonathan, she finds herself enchanted by his vibrant spirit, which breathes new life into the otherwise staunch hotel environment dictated by Dracula’s strict rules. In a moment of bonding, Dracula even shares the heartbreaking story of Mavis’s mother, whose life was claimed by humans, solidifying his resolve to keep her insulated from the outside world. However, after Mavis’s birthday party, Jonathan decides to leave, recognizing that humans might never accept monsters like Dracula and his family.

Tragedy strikes as Chef Quasimodo Wilson uncovers Jonathan’s true identity and seeks to cook him, leading to a frantic rescue mission by Dracula, who uses his magical powers to hold the chef in place. The party is a cacophony of laughter and joy until a shocking kiss between Jonathan and Mavis sends Dracula into a panic. In a hasty revelation, he admits to Mavis that he has misled her regarding the potential dangers of humans, causing a rift between father and daughter.

With his heart heavy, Dracula realizes that his efforts to safeguard Mavis may have inadvertently led to her heartbreak as she wishes to remain with him forever. Stricken with guilt, he enlists the help of his monstrous friends to find Jonathan and even dares to brave the sunlight to do so. They find themselves in a town celebrating a ‘Monster Festival,’ where their presence is surprisingly welcomed by the humans.

In a desperate dash, Dracula leaps into action as Jonathan’s plane prepares to take off. With immense determination, he pursues the aircraft, risking injury from the sunlight. Ultimately, he uses his powers to communicate with Jonathan, conveying his desire for him to return to Mavis. Accepting Dracula’s heartfelt apology, Jonathan agrees to come back, allowing the two to reunite.

In a triumphant return to the hotel, Dracula bestows his approval upon Jonathan and Mavis’s relationship, prompting a celebratory gathering that marks a new chapter in both their lives. The film concludes with a nostalgic touch, showing Dracula and his companions animated in the whimsical style reminiscent of Genndy Tartakovsky’s signature cartoons during the credit roll.