Earl Keese, portrayed by John Belushi, is your typical middle-aged suburban husband who finds himself caught in an unexpected whirlwind of misadventure. After coming home from a long day at work, he settles down in front of the television, trying to unwind. However, his mundane routine is interrupted when he notices a moving truck at the neighboring house in their quiet cul-de-sac. Curiosity gets the better of him, and he suggests to his wife, Enid, played by Kathryn Walker, that they should welcome the new neighbors with an invitation for drinks. Unfortunately, Enid is too preoccupied with cooking dinner and shows little interest.

The doorbell interrupts their conversation, and Earl meets his alluring new neighbor, Ramona, portrayed by Cathy Moriarty. Upon inviting her in for dinner, he soon finds out that a little issue arises—Enid hasn’t had time for grocery shopping, leaving them with only frozen waffles as a meal. When he returns to invite Ramona for dinner, he realizes that she has discreetly slipped away but has left behind her husband, Vic, vividly brought to life by Dan Aykroyd. Vic takes the opportunity to offer his assistance by suggesting they order Italian food, promising to bring it back if Earl hands over some cash.

Feeling uneasy, Earl complies but grows suspicious when Vic requests his car keys, claiming his truck’s brakes are malfunctioning. Intrigued but troubled by the situation, Earl heads upstairs to fetch the keys from Enid’s purse only to stumble upon a shocking sight—Ramona is lying naked in his bed, saying she needs a rest after moving in.

As events unfurl, Vic drives off with the keys, leaving Earl suspicious and on edge. Earl sneaks over to the neighbors’ house and witnesses Vic cooking spaghetti in their kitchen, about to pass the off as takeout. Believing he can play a prank, Earl decides to hide Vic’s truck in his garage, but in a twist of fate, finds that the brakes are indeed faulty. The truck speeds uncontrollably off into a nearby swamp, sinking without a trace.

Moments later, Vic returns with what he claims is the takeout meal along with wine, catching Enid’s eye. The delightful dinner quickly spirals into chaos as Earl confronts Vic about the food, leading to startling admissions. Ramona then falsely accuses Earl of trying to seduce her, creating a rift between the neighbors as they vow not to pursue any legal action while living so close together.

As the tension builds between the couples, an electric surge suddenly zaps Vic and Ramona’s dog, much to everyone’s alarm. Before long, Earl and Vic hatch a plan to retrieve the submerged truck, only for Earl to stumble into quicksand. Although Vic manages to pull Earl out, he soon finds himself trapped in the very same quicksand. After a chaotic series of events, Earl believes Vic is dead, only to be surprised when a mud-covered Vic reappears, adding to the absurdity of their situation.

In a more bizarre turn of events, Earl finds himself locked in his own basement while Vic and Ramona sneak about upstairs, leading him to reach out for help from a local locksmith. Meanwhile, Earl’s teenage daughter, Elaine, unexpectedly returns home, bringing along a bottle of vodka and ready to party with the new neighbors.

The ensuing mayhem concludes with Earl’s outdoor antics, leading him to inadvertently develop a bizarre relationship with Ramona that culminates in a chaotic miscommunication with Vic and a series of comedic mishaps. As Vic reveals that he’s actually moving out of the neighborhood due to the swamp and its bugs, Earl finds himself inadvertently tangled in the web of their absurd lives. He even offers his car to Vic as a parting gift.

In the end, after discovering that Vic and Ramona are not the homeowners and have no insurance for the chaos they’ve caused, Earl confronts the reality of his mundane suburban life. When Vic and Ramona depart, Earl, feeling an unexpected void, prepares to embrace the “great unknown,” igniting a fire as he realizes that with all their eccentricities, life was never dull with his unpredictable neighbors.

In this rollercoaster of absurdity, Earl, Vic, and Ramona step boldly into the unforeseen journey ahead, promising adventure and uncertainty, a stark contrast to their previously banal existence.