Osmosis Jones 2001

Frank Detorre, a slovenly widower and zookeeper at the Sucat Memorial Zoo in Rhode Island, leads a life filled with unhealthy habits that exasperate his young daughter, Shane. He eats compulsively and shows little regard for germs or hygiene. During one particularly grotesque meal involving a hard-boiled egg smeared with mayonnaise and salt, Frank is thwarted by a mischievous chimpanzee that snatches the egg away. Although he retrieves it, it meets a grim fate in the mess of the chimp’s habitat. When Shane expresses her disgust at her father’s unsanitary snack, Frank shamelessly defends his actions with the infamous > “ten second rule.”

Within Frank’s body, Osmosis “Ozzy” Jones, a witty and adventurous white blood cell, finds himself on an unconventional mission. This rebellious agent of the Frank PD often disregards protocol in pursuit of what he believes is right, earning him the scorn of his fellow cells. After an embarrassing incident where he inadvertently makes Frank vomit all over Shane’s science teacher, Mrs. Boyd, at the science fair—under the mistaken belief that a raw oyster posed a threat—Ozzy is reassigned to the mouth to combat germs.

The body soon becomes a battleground when newcomer germs hijack a squad car inside Frank’s mouth, prompting an action-packed chase that climaxes with a massive yawn pulling Ozzy and his partner, the cold-suppressant pill Drix (Drixenol “Drix” Koldreliff), into the lungs. Although ordered to stand down, Ozzy defies orders in a pursuit that inadvertently triggers a cramp in Frank’s leg. Meanwhile, Mayor Phlegmming faces re-election, promising junk food despite it being one of the factors behind Frank’s declining health.

As if the situation wasn’t dire enough, a lethal virus known as Thrax emerges, having hitchhiked along with Frank’s hard-boiled egg. Determined to downplay the emergency, Phlegmming instructs Frank to take the Drix pill, which arrives to quell the irritation in Frank’s throat. As Ozzy begrudgingly partners with Drix, they learn from a common influenza virus about Thrax’s sinister plan to masquerade as a harmless cold while plotting Frank’s demise through a fever.

The tense confrontation ensues in one of Frank’s zits, where Drix detonates a grenade of medicine, effectively popping the blemish and annihilating nearly all of Thrax’s minions. However, Thrax survives the explosion and attacks Frank’s hypothalamus, diminishing its ability to self-regulate and stealing critical DNA. Chaos erupts as Frank’s body temperature escalates dangerously, necessitating an emergency trip to the hospital just as Ozzy and Drix embark on a rescue mission for Leah Estrogen, the mayor’s secretary, who has been taken hostage by Thrax.

A gripping showdown occurs on one of Shane’s eyeballs, where Ozzy intervenes just in time to save her from Thrax’s lethal intentions, ultimately causing Thrax to meet his end in a vessel of alcohol below. Meanwhile, the internal crisis reaches a fever pitch, pushing Frank into cardiac arrest as the doctors seem ready to concede defeat. In a moment of salvation, Ozzy returns to Frank’s body with a tear from Shane, which contains the missing hypothalamus chromosome, bringing Frank back to life.

Reinstated in “Immunity” with newfound accolades, Ozzy and Drix emerge as heroes, while Frank begins to turn his life around, looking after his health and hygiene with renewed determination. In an ironic twist, Mayor Phlegmming faces a fall from grace, finding himself reduced to the role of a janitor in the bowels, where he accidentally ejects himself by triggering a forbidden button that sets off Frank’s farting.